Anna is head of Bioinformatics at the Medical Genetics Centre Munich and a research coordinator for the German Human Genome Archive (GHGA) at the Helmholtz Munich. Since 2019 she is also a scientific collaborator at UCSC Genome Browser.

She has a PhD in human genetics and is a specialist in the field of genome sequencing and data analysis with a strong background in the clinical genetics of Rare Diseases. She has many years of experience in interdisciplinary management of laboratory technology, bioinformatics, and scientific development in academic, clinical and private practice environments.

Anna is an advocate for the use of best practices in FAIR data management and sharing strategies to maximize the use of OMICS data and improve the diagnosis of genetic disorders. She has contributed to publications on guidelines for utilization of next-generation sequencing approaches in clinical genetics testing and she is assessor of the External Quality Assessment scheme for Charcot-Marie-Tooth disease within the European Genetics Quality Network (EMQN) framework. She strongly believes in the power of education and is therefore an active member of the HUGO Education Committee and an instructor at the Variant Effect Prediction Training Course (VEPTC).

The focus of my research at the University of Zurich is the analysis of structural variations in cancer genomes by computational genomics, including bioinformatics and systems biology methods. My work centers around our collection of genomic tumor data, assembled from copy number screening experiments in cancer. Specific projects deal with the development of computational methods for cancer genome data analysis, genomic aberration analysis in specific tumor entities as well as large scale exploration of imbalance patterns in malignancies.

An important aspect of my group's work is the curation of public cancer genome datasets. The Progenetix project is a reference database for (molecular-) cytogenetic aberration data in human malignancies. Currently, the Progenetix database contains results from more than 31000 genomic profiling experiments using chromosomal, array and sequencing based genome screening techniques. In 2012, my group published a resource aimed at collection, re-analysis and probe-level visualization of oncogenomic array data. This "arrayMap" resource can be accessed at arraymap.org.

Aside from general CNA data collection and software development, my group is involved in cancer type specific analysis projects. These studies are usually collaborative projects, with a current focus on childhood brain tumors and cutaneous lymphomas.

Since 2014 I have been a member of the Global Alliance for Genomics and Health, where I am one of the leaders of the metadata task team inside the Data Working Group as well as as member of several workstreams. As part of the DWG, the metadata task team was concerned with the definition of modern, standardised data schemas facilitating unambiguous annotation and mining of attributes describing e.g. provenance as well as biological or biomedical attributes associated with physical or procedural objects, related to genomic data structures. Since December 2018, i am co-chair of the GA4GH "Discovery" workstream.

Victor Guryev was trained as molecular biologist at Novosibirsk State University and received his PhD from Institute of Cytology and Genetics (Novosibirsk, Russia) in 2002. As a postdoc he joined groups of Prof. Ronald Plasterk and Dr. Edwin Cuppen at Hubrecht Institute to work on discovery and characterization of natural and induced genetic differences in model organism (rat, zebrafish, C. elegans) and characterization of their haplotype structure. Since 2006 his primary interest has been in functional consequences of structural changes in genomes. He constructed the first map of copy-number variants in rat and showed their effect on gene expression. Fascinated by structural plasticity of mammalian genomes, he combines his bioinformatics expertise and recent technological advances, such as high-throughput sequencing, to investigate dynamics of genome changes in populations and individual organisms. He is involved in several projects studying small- and large-scale genome structure variations in human and laboratory rat populations. Victor is currently a faculty member of Netherlands Bioinformatics Centre (NBIC) and was the head of bioinformatics at Hubrecht Institute until summer 2012.

At ERIBA, Victor’s research is focused on studying changes of structural genome variation and its role in ageing.

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